Uniform TitleThe physics of chromatin silencing: bi-stability and front propagation
NameSedighi, Mohammad (author), Sengupta, Anirvan (chair), Ruckenstein, Andrei (internal member), Cheong, Sang-Wook (internal member), Lukyanov, Sergei (internal member), Mukhopadhyay, Ranjan (outside member), Rutgers University, Graduate School-New Brunswick,
SubjectPhysics and Astronomy,
DescriptionA mean-field dynamical model of chromatin silencing in budding yeast is provided and the conditions giving rise to two states: one silenced and another un-silenced, is studied. Based on these conditions, the space of control parameters is divided into two distinct regions of mono-stable and bi-stable solutions (the bifurcation diagram). Then, considering both the discrete and continuous versions of the model, the formation of a stable boundary between the silenced and un-silenced areas on DNA is investigated. As a result, a richer phase diagram is provided. The dynamics of the boundary is also studied under different conditions. Consequently, assuming negative feedback due to possible depletion of silencing proteins, the model explains a paradoxical epigenetic behavior of yeast that happens under some mutation. A stochastic treatment of the model is also considered to verify the results of the mean-field approximation and also to understand the role of intrinsic noise at single cell level. This model could be used as a general guide to discuss chromatin silencing in many organisms.
Note[bibliography] Includes bibliographical references (p. 77-79).
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.