TitleEffect of Quantitative Nuclear Image Features on Recurrence of Ductal Carcinoma In Situ (DCIS) of the Breast
Uniform TitleCancer Informatics
NameAxelrod, David E. (author), Miller, Naomi A. (author), Lickley, H. Lavina (author), Qian, Jin (author), Christens-Barry, William A. (author), Yuan, Yan (author), Fu, Yuejiao (author), Chapman, Judith-Anne W. (author), National Institutes of Health (U.S.), New Jersey Commission on Cancer Research,
Breast ductal carcinoma in situ
DescriptionBACKGROUND: Nuclear grade has been associated with breast DCIS recurrence and progression to invasive carcinoma; however, our previous study of a cohort of patients with breast DCIS did not find such an association with outcome. Fifty percent of patients had heterogeneous DCIS with more than one nuclear grade. The aim of the current study was to investigate the effect of quantitative nuclear features assessed with digital image analysis on ipsilateral DCIS recurrence.
CONCLUSION: Analysis of nuclear features measured by image cytometry may contribute to the classification and prognosis of breast DCIS patients with more than one nuclear grade.
NoteAuthor manuscript. Published in final edited form as: Cancer Informatics 2008:4 99–109.
NoteThe final published version of this article is located at: http://la-press.com/article.php?article_id=583
NoteNIH U56 CA113004; to David E. Axelrod
NoteThis work was funded by the New Jersey Commission for Cancer Research 1076-CCRS0, the National Institutes of Health U56 CA113004, the Hyde and Watson Foundation, the Busch Memorial Fund, and the E.B. Fish Research Fund.
NoteNJ Commission on Cancer Research 1076-CCR-SO; to David E. Axelrod
CollectionAxelrod, David Collection
Organization NameRutgers, The State University of New Jersey
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