TitleBlood lead levels increase, but remain in normal range with severe weight reduction.
PublisherNature Publishing Group
NameShapses, Sue (author), Riedt, Claudia (author), Buckley, Brian (author), Ambia-Sobhan, Hasina (author), Rhoads, George (author), Brolin, Robert E. (author), National Institutes of Health (U.S.), National Institute of Environmental Health Sciences,
DescriptionHigh bone turnover states are known to raise blood lead levels (BPb). Caloric restriction will increase bone turnover, yet it remains unknown if weight reduction increases BPb due to mobilization of skeletal stores. We measured whole blood Pb levels (²⁰⁶Pb) by inductively coupled plasma mass spectrometry in 73 women (age 24–75 years; BMI 23– 61 kg/m²) before and after 6 months of severe weight loss (S-WL), moderate weight loss (M-WL), or weight maintenance (WM). Baseline BPb levels were relatively low at 0.2–6.0 μg/dl, and directly associated with age (r=0.49, P<0.0001). After severe WL (-37.4±9.3 kg, n=17), BPb increased by 2.1±3.9 μg/dl (P<0.05), resulting in BPb levels of 1.3–12.5 μg/dl. M-WL (-5.6±2.7 kg, n=39) and WM (0.3±1.3 kg, n=17) did not result in an increase in BPb levels (0.5±3.2 and 0.0±0.7 μg/dl, M-WL and WM, respectively). BPb levels increased more with greater WL (r=0.24, P<0.05). Bone turnover markers increased only with severe WL and were directly correlated with WL. At baseline, higher calcium intake was associated with lower BPb (r=-0.273, P<0.02), however, this association was no longer present after 6 months. Severe weight reduction in obese women increases skeletal bone mobilization and BPb, but values remain well below levels defined as Pb overexposure.
NoteJournal of Exposure Science and Environmental Epidemiology (2008), 1–7
NoteThis research was supported by the NIEHS sponsored UMDNJ Center for Environmental Exposures and Disease, Grant number: NIEHS P30ES005022, in part by NIH-AG12161, and a Busch Biomedical Award to SA Shapses.
NoteNational Institute of Environmental Health Sciences: P30ES005022
NoteNational Institutes of Health: AG12161, to S.A. Shapses
NoteCharles & Johanna Busch Biomedical Grant, to S.A. Shapses
NoteThe published version of this paper is available at: http://www.nature.com/jes
CollectionShapses Sue Collection
Organization NameRutgers, The State University of New Jersey
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