Uniform TitleControlled-release antimicrobials for preventing biofilm formation in food and medical applications
NameRosenberg, Linda E. (author), Chikindas, Michael (chair), Takhistov, Paul (internal member), Daun, Henryk (dissertation committee member), Rutgers University, Graduate School - New Brunswick,
DescriptionBacterial biofilms generally are more resistant to stresses as compared to free planktonic cells. Therefore, the discovery of antimicrobial stress factors that have strong inhibitory effects on bacterial biofilm formation would have great impact on the food, personal care, and medical industries. Biofilm formation can be prevented through controlled release of nature-derived antimicrobials formulated into polymer systems, especially those featuring multiple stresses as hurdles for the bacteria to overcome to prevent the development of resistance. Salicylate-based poly(anhydride-esters) have previously been shown to inhibit biofilm formation. Our research evaluated the effect of salicylate-based poly(anhydride-esters) on biofilm forming Salmonella enterica serovar Typhimurium. The results indicate that the salicylic acid-based polymers do interfere with biofilm formation through a combination of pH effects and a thus-far-unknown mechanism. Systems combining pH stress with the controlled release of natural antimicrobials have great potential to prevent biofilm development in many environments to prevent adverse outcomes, especially implant contamination and foodborne illness.
NoteIncludes bibliographical references (p. 67-74).
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.