Uniform TitleFluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine
NameSteege, Karen Elizabeth (author), Castner, Edward (chair), Uhrich, Kathryn (internal member), Arnold, Edward (internal member), Piotrowiak, Piotr (outside member), Rutgers University, Graduate School - New Brunswick,
SubjectChemistry and Chemical Biology,
Drug delivery systems
DescriptionThe local environment of a drug molecule in polymeric drug nanocarrier solutions impacts the bioavailability of the drug and its ability to reach its target in the biological system. The local environment and aggregation properties of small, hydrophobic molecules in aqueous polymeric micelles and nanocarrier aggregates are explored using fluorescence spectroscopy for the purpose of characterizing drug delivery formulations on molecular length scales. The
fluorescence properties of seven coumarin dyes in A-B-A triblock copolymer unimer, micelle, and gel solutions respond to changes in local solvent environment. The A-B-A copolymer is used as a model for the encapsulation
properties of three novel amphiphilic polymers designed for hydrophobic drug delivery. Rilpivirine, a novel HIV inhibitor shows solvatochromic fluorescence spectral response due to a large charge transfer between the ground and electronic excited states. The fluorescence of rilpivirine in A-B-A triblock copolymer is investigated as a method to differentiate between the aggregated and unimer forms of the solubilized drug.
NoteIncludes bibliographical references.
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.