TitleAnti-obesity effects of resveratrol, black tea extract and caffeine in mice
NameChen, Tzu-Ying (author), HUANG, QINGRONG (chair), DAUN, HENRYK (internal member), HUANG, MOU-TUAN (outside member), Rutgers University, Graduate School - New Brunswick,
Weight loss preparations,
DescriptionObesity continues to be a major public health issue in the United States. The aims of this study were to investigate whether the dietary resveratrol, black tea extract, caffeine and their combination could show anti-obesity effects in CD-1 mice fed with a high-fat diet. Five groups of CD-1 mice, with 10 mice in each group, were fed with 0.06 % resveratrol (RTL), 0.2 % black tea extract (BTE) and 0.05 % caffeine (CF), as well as their combination containing 0.03 % RTL, 0.1 % BTE and 0.025 % CF for 16 weeks. Mice on the CF diet significantly (p[less than]0.01) reduced body weight gain by 46 %, while those on the RTL, BTE, CF and the combination diets showed reductions by 12 %, 14 % and 28 %, respectively. There were significant inhibitions in parametrial (77 %), retroperitoneal (77 %) fat pads and brown adipose tissue (57 %) for mice on CF group.
Mice on the BTE diet showed significant (p[less than]0.05) inhibition of leptin levels in plasma by 59 %, while those on the CF and combination diets demonstrated significant (p[less than]0.01) inhibition by 88 % and 79 %, respectively. These results suggest that diets with RTL, BTE, and CF reduced body weight gain, fat tissue depositions and leptin levels in female CD-mice during the 16-week animal studies.
NoteIncludes bibliographical references (p. 72-75).
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
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