TitleThe bed nucleus of the stria terminalis mediates inter-individual variations in anxiety and fear
PublisherSociety for Neuroscience
NameDuvarci, Sevil (Author), Bauer, Elizabeth P. (Author), Pare, Denis (Author), National Institutes of Health,
Bed nucleus of the stria terminalis (BNST)
DescriptionWhile learning to fear stimuli that predict danger promotes survival, the inability to inhibit fear to inappropriate cues leads to a pernicious cycle of avoidance behaviors. Previous studies have revealed large inter-individual variations in fear responding with clinically anxious humans exhibiting a tendency to generalize learned fear to safe stimuli or situations. To shed light on the origin of these inter-individual variations, we subjected rats to a differential auditory fear conditioning paradigm where one conditioned auditory stimulus (CS+) was paired to footshocks whereas a second (CS-) was not. We compared the behavior of rats that received pre-training excitotoxic lesions of the bed nucleus of the stria terminalis (BNST) to that of sham rats. Sham rats exhibit a continuum of anxious/fearful behaviors. At one end of the continuum were rats that displayed a poor ability to discriminate between the CS+ and CS-, high contextual freezing, and an anxiety-like trait in the elevated plus maze (EPM). At the other end were rats that display less fear generalization to the CS-, lower freezing to context, and a non-anxious trait on the EPM. Although BNST-lesioned rats acquired similarly high levels of conditioned fear to the CS+, they froze less than sham rats to the CS-. In fact, BNST-lesioned rats behaved like sham rats with high discriminative abilities in that they exhibited low contextual fear and a nonanxious phenotype in the EPM. Overall, this suggests that inter-individual variations in fear generalization and anxiety phenotype are determined by BNST influences on the amygdala and/or its targets.
NotePublished in Journal of Neuroscience. Copyright Society for Neuroscience.
NoteAvailable from the Journal of Neuroscience: http://www.jneurosci.org/
NoteThe Journal of Neuroscience, August 19, 2009 • 29(33):10357–10361
CollectionParÃ©, Denis Collection
Organization NameRutgers, The State University of New Jersey
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