TitleDevelopment of novel bimetallic chiral complexes & formation of cyclic aminals under under Friedländer conditions
NameMal, Rudajit (author), Seidel, Daniel (chair), Knapp, Spencer (internal member), Hultzsch, Kai (internal member), Rutgers University, Graduate School - New Brunswick,
SubjectChemistry and Chemical Biology,
DescriptionThe design of new chiral binuclear ligands was undertaken to address the challenge of catalyzing nucleophilic additions to simple α,β- unsaturated carbonyl compounds. The designs were based on natural bimetallic enzymes as well as on synthetic achiral bimetallic complexes. Ligands with different electronic and structural properties were synthesized and a variety of transition metal complexes prepared. Their catalytic activities were tested in 1,4-additions of indole to α,β-unsaturated carbonyl compounds. Single X-ray crystallography was used to gain an insight into the nature of these newly developed chiral bimetallic complexes. Efforts were made to synthesize chiral bimetallic complexes derived from amino indanol.
A new reaction methodology was investigated to form cyclic aminals from aminobenzaldehydes and secondary amines. The methodology was shown to be successful for broad range of substrates. L-proline could be used in place of secondary amines in a decarboxylative variant of the reaction. The use of microwave irradiation was explored as a means to extend the scope of this methodology.
NoteIncludes bibliographical references
Noteby Rudrajit Mal
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.