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TitleDevelopment of novel bimetallic chiral complexes & formation of cyclic aminals under under Friedländer conditions
NameMal, Rudajit (author), Seidel, Daniel (chair), Knapp, Spencer (internal member), Hultzsch, Kai (internal member), Rutgers University, Graduate School - New Brunswick,
Degree Date2010
Date Created2010
SubjectChemistry and Chemical Biology,
Ligands (Biochemistry)
DescriptionThe design of new chiral binuclear ligands was undertaken to address the challenge of catalyzing nucleophilic additions to simple α,β- unsaturated carbonyl compounds. The designs were based on natural bimetallic enzymes as well as on synthetic achiral bimetallic complexes. Ligands with different electronic and structural properties were synthesized and a variety of transition metal complexes prepared. Their catalytic activities were tested in 1,4-additions of indole to α,β-unsaturated carbonyl compounds. Single X-ray crystallography was used to gain an insight into the nature of these newly developed chiral bimetallic complexes. Efforts were made to synthesize chiral bimetallic complexes derived from amino indanol.
A new reaction methodology was investigated to form cyclic aminals from aminobenzaldehydes and secondary amines. The methodology was shown to be successful for broad range of substrates. L-proline could be used in place of secondary amines in a decarboxylative variant of the reaction. The use of microwave irradiation was explored as a means to extend the scope of this methodology.
A new reaction methodology was investigated to form cyclic aminals from aminobenzaldehydes and secondary amines. The methodology was shown to be successful for broad range of substrates. L-proline could be used in place of secondary amines in a decarboxylative variant of the reaction. The use of microwave irradiation was explored as a means to extend the scope of this methodology.
NoteM.S.T.
NoteIncludes abstract
NoteIncludes bibliographical references
Noteby Rudrajit Mal
Genretheses
Persistent URLhttp://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000053349
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.