TitleDevelopment of catalytic enantioselective Aldol, Mannich, Friedlaender reactions
NameLi, Le (author), Seidel, Daniel (chair), Hultzsch, Kai (internal member), Zhang, Xumu (internal member), Zhang, Haiming (outside member), Rutgers University, Graduate School - New Brunswick,
SubjectChemistry and Chemical Biology,
Diamino amino acids
DescriptionIn Chapter I, I introduce the explosive development of enantioselective organocatalysis. Selected significant landmarks in this area are reviewed and highlighted in this chapter. Chapter II focuses on the development of catalytic enantioselective aldol additions of α-isothiocyanato imides to aldehydes and α-ketoesters. Chapter III outlines the development of enantioselective Mannich reactions of α-isothiocyanato imides with activated imines and the asymmetric synthesis of α, β-diamino acid derivatives. In Chapter IV, the first catalytic enantioselective Friedländer condensation is described which provides access to quinolines and tacrines with remote stereogenic centers.
NoteIncludes bibliographical references
Noteby Le Li
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.