RUcore Resource Object
RUcore Resource Object
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TitleDrop on demand technology as a mini manufacturing platform for drug delivery and personalized medicine
NameSahay, Abhishek (author), Takhistov, Paul (chair), Shreiber, David (internal member), Michniak, Bozena (internal member), Rutgers University, Graduate School - New Brunswick,
Degree Date2012-01
Date Created2012
SubjectBiomedical Engineering,
Drug delivery systems,
Pharmaceutical technology
DescriptionThere is need to develop a process and technology through which small tailored dosages can be delivered with precision and accuracy. This has led to research on developing a manufacturing platform which could be used to deliver personalized drugs in a variety of dosage formats both cheaply and efficiently. We envision a mini manufacturing platform centered on Drop-on-Demand (DoD) technology which can have wide ranging applications such as personalized medicine, clinical trials, poly-pharmacy and distributed manufacturing. A prototype system has been developed that has been tested for accuracy using gravimetric methods for dispensing sample dosage formats. The incorporation of online analytics has also been explored. Three sets of experiments were conducted. In the first one, the accuracy of the system was measured experimentally using gravimetric methods. The dispensing system was found to be very accurate with RSD < 1% and this was true for dispensing solutions as well as suspensions. In the second experiment the effect of viscosity was studied. It was found that for a fixed set of variables such as input pressure and nozzle diameter there was a limiting viscosity above which the dispensing was disrupted. The aggregation behavior of suspensions during flow through micro capillary was also studied. Finally the applicability of Raman spectroscopy for in line analytics was tested experimentally. It was found that Raman can be used for qualification of API in-capsule as well as in the supply line.
NoteM.S.
NoteIncludes bibliographical references
Noteby Abhishek Sahay
Genretheses
Persistent URLhttp://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000064169
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.