TitleThe effects of Wnt5a and Wnt3a and PCP signaling on Schwann cell biology and myelination
NameJani, Neha (author), Maurel, Patrice (chair), Gao, Nan (internal member), Melendez-Vasquez, Carmen (outside member), Rutgers University, Graduate School - Newark,
DescriptionPlanar cell polarity (PCP) is known as the polarization of cells within the plane of the tissue layer. This form of polarization controls several epithelial and non-epithelial morphological processes, such as the orientation of primary cilia in the inner ear, convergent extension (CE) and directed migration. A three tiered model of PCP regulation has been proposed which consists of the global, core, and effector modules. However there is one addition level of modulation through non-canonical Wnt signaling pathway. Of the many Wnt proteins a few have been identified to signal primarily through this pathway. One such protein is Wnt5a, which has been shown to modulate PCP during directed cell migration. In this study we gather preliminary data for the presence of PCP signaling components in Schwann cells and investigate the effect of Wnt5a and its antagonist Wnt3a on Schwann cell proliferation, migration and myelination.
NoteIncludes bibliographical references
Noteby Neha Jani
CollectionGraduate School - Newark Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.